CatalogueOfSomaticMutationsInCancer

http://www.sanger.ac.uk/genetics/CGP/cosmic/

[[WikiPedia:COSMIC_cancer_database]]. Somatically acquired mutations found in human [[Cancer]] from literature by SangerCenter. 

Release v48 (July 2010) describes over 136,000 coding mutations in almost 542,000 tumour samples; of the 18,490 genes documented, 4803 (26%) have one or more mutations. Full scientific literature curations are available on '''83 major cancer genes and 49 fusion gene pairs''' (19 new cancer genes and 30 new fusion pairs this year) and this number is continually increasing. Key amongst these is [[TP53]], now available through a collaboration with the [[IARC_TP53_Database]]. In addition to data from the CancerGenomeProject ([[CGP]]) at the SangerCenter, UK, and TheCancerGenomeAtlas project ([[TCGA]]), large systematic screens are also now curated. Major website upgrades now make these data much more mineable, with many new selection filters and graphics. A [[BioMart]] is now available allowing more automated data mining and integration with other BiologicalDatabase. 

관련논문
 * [[http://nar.oxfordjournals.org/content/39/suppl_1/D945.long|COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer]]
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CategoryDatabase