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CategoryBook
[[Proteins]] may be broken into their constitutent monomer molecules by hydrolysis. AminoAcid products of the reaction constitute the AminoAcid composition of the [[Proteins]].

 * Standard AminoAcid : 20 amino acids found in [[Proteins]]
 * Nonstandard AminoAcid : chemically mdified after their incorporation into a polypeptide and amino acids that occur in living organisms but are not found in [[Proteins]]. e.g.taurin

These molecules contain a central carbon atom (''alpha''-carbon) to which an amino group, a carboxylate group, a hydrogen atom, and an R(side chain) group are attached.

At a pH of 7 the carboxyl group of an AminoAcid is in its conjugate base form (-COO-) and the amino group is in its conjugate acid form (-NH3+). Thus each AminoAcid can behave as either an acid or a base. It's called '''Amphoteric''' property of a AminoAcid. Neutral molecules that bear an equal number of positive and negative charges simultaneously are called '''zwitterions'''. It is the R group, however, that gives each AminoAcid its unique properities. Also the pH value that AminoAcid's net charge become zero is called IsoelectricPoint.

=== Names and Abbreviations of the Standard amino acids ===

||'''AminoAcid'''||'''Three-Letter'''||'''One-Letter'''||
||Alanine||Ala||A||
||Arginine||Arg||R||
||Asparagine|| Asn ||N||
||Aspartic acid ||Asp ||D||
||Cysteine ||Cys ||C||
||Glutamic acid ||Glu ||E||
||Glutamine ||Gln ||Q||
||Histidine ||His ||H||
||Isoleucine ||Ile ||I||
||Leucine ||Leu ||L||
||Lysine ||Lys ||K||
||Methionine ||Met ||M||
||Phenylalanine ||Phe ||F||
||Proline ||Pro ||P||
||Serine ||Ser ||S||
||Threonine ||Thr ||T||
||Tryptophan ||Trp ||W||
||Tyrosine ||Tyr ||Y||
||Valine ||Val ||V||

Special AminoAcid
|| SelenoCystein || Sec || U ||

=== Classification of Amino acids ===
 Group I : Hydrophobic - Nonpolar side Chains
           Ala, Val, Leu, Ile, Pro, Met, Phe, Trp
 
 Group II : Polar, unchanged
            Gly, Ser, Thr, Cys,Tyr, Asn, Gln
 
 Group III : Acidic
            Asp, Glu
 
 Group IV : Basic
            Lys, Arg, His


=== Properties of each Amino acids ===
♣Histidine(His, H)
 Unique imidazole side chain: effective as nucleophilic catalyst( more basic than hydroxide ion)

 five-membered ring structure --> relatively little steric hindrance

 pKa = 7

<Aromatic Residues>
 Has UV absorbance and fluorescence properties of proteins.

=== AminoAcid chart ===

{{http://www.ionsource.com/virtit/VirtualIT/chart1.gif}}

=== 필수 AminoAcid ===

체내에서 합성이 되지 않기 때문에 반드시 섭취해야 하는 8가지 AminoAcid들
 Ile, Leu, Val, Lys, Phe, Trp, Met, Thr

Proteins may be broken into their constitutent monomer molecules by hydrolysis. AminoAcid products of the reaction constitute the AminoAcid composition of the Proteins.

  • Standard AminoAcid : 20 amino acids found in Proteins

  • Nonstandard AminoAcid : chemically mdified after their incorporation into a polypeptide and amino acids that occur in living organisms but are not found in Proteins. e.g.taurin

These molecules contain a central carbon atom (alpha-carbon) to which an amino group, a carboxylate group, a hydrogen atom, and an R(side chain) group are attached.

At a pH of 7 the carboxyl group of an AminoAcid is in its conjugate base form (-COO-) and the amino group is in its conjugate acid form (-NH3+). Thus each AminoAcid can behave as either an acid or a base. It's called Amphoteric property of a AminoAcid. Neutral molecules that bear an equal number of positive and negative charges simultaneously are called zwitterions. It is the R group, however, that gives each AminoAcid its unique properities. Also the pH value that AminoAcid's net charge become zero is called IsoelectricPoint.

Names and Abbreviations of the Standard amino acids

AminoAcid

Three-Letter

One-Letter

Alanine

Ala

A

Arginine

Arg

R

Asparagine

Asn

N

Aspartic acid

Asp

D

Cysteine

Cys

C

Glutamic acid

Glu

E

Glutamine

Gln

Q

Histidine

His

H

Isoleucine

Ile

I

Leucine

Leu

L

Lysine

Lys

K

Methionine

Met

M

Phenylalanine

Phe

F

Proline

Pro

P

Serine

Ser

S

Threonine

Thr

T

Tryptophan

Trp

W

Tyrosine

Tyr

Y

Valine

Val

V

Special AminoAcid

SelenoCystein

Sec

U

Classification of Amino acids

  • Group I : Hydrophobic - Nonpolar side Chains
    • Ala, Val, Leu, Ile, Pro, Met, Phe, Trp
    Group II : Polar, unchanged
    • Gly, Ser, Thr, Cys,Tyr, Asn, Gln
    Group III : Acidic
    • Asp, Glu
    Group IV : Basic
    • Lys, Arg, His

Properties of each Amino acids

♣Histidine(His, H)

  • Unique imidazole side chain: effective as nucleophilic catalyst( more basic than hydroxide ion)

    five-membered ring structure --> relatively little steric hindrance pKa = 7

<Aromatic Residues>

  • Has UV absorbance and fluorescence properties of proteins.

AminoAcid chart

http://www.ionsource.com/virtit/VirtualIT/chart1.gif

필수 AminoAcid

체내에서 합성이 되지 않기 때문에 반드시 섭취해야 하는 8가지 AminoAcid들

  • Ile, Leu, Val, Lys, Phe, Trp, Met, Thr

AminoAcid (last edited 2011-08-03 11:00:46 by localhost)

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