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This 3D-structure of [DNA] is formed in the [Telomere] region and inhibit the telemrase. In addition, it has been found in the [Promoter] region of several [Gene]s inclucing OncoGene. Recently, there has been many interests in G-quadruplex stabiling ligands as anti-cancer.
When the G-quadruplex is formed,RNA polymerase or telomerase can't move forward and then, the product, transcript or telomere which induces cellular transformation, is not generated.

[DNA] 4중나선 구조. G-Quadruplex

This 3D-structure of [DNA] is formed in the [Telomere] region and inhibit the telemrase. In addition, it has been found in the [Promoter] region of several [Gene]s inclucing OncoGene. Recently, there has been many interests in G-quadruplex stabiling ligands as anti-cancer. When the G-quadruplex is formed,RNA polymerase or telomerase can't move forward and then, the product, transcript or telomere which induces cellular transformation, is not generated.

관련프로그램

Quadruplex (last edited 2011-11-30 18:49:32 by 152)

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