BioHackersNet|
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| This 3D-structure of DNA is formed in the telemere region and inhibit the telemrase. In addition,it has been found in the promoter region of several genes inclucing oncogene. Recently, there has been many interests in G-quadruplex stabiling ligands as anti-cancer. |
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| 관련프로그램 | This 3D-structure of [DNA] is formed in the [Telomere] region and inhibit the telemrase. In addition, it has been found in the [Promoter] region of several [Gene]s inclucing OncoGene. Recently, there has been many interests in G-quadruplex stabiling ligands as anti-cancer. When the G-quadruplex is formed,RNA polymerase or telomerase can't move forward and then, the product, transcript or telomere which induces cellular transformation, is not generated. In addition, [RNA] G-Quadruplexes have been found in [HIV] and human. Human RNA G-quadruplexes play roles in regulating RNA-processing like polyadenylation or RnaSplicing. 관련프로그램 및 Database |
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| * [http://bioinformatics.ramapo.edu/grsdb/index.php GRSDB] |
[DNA] 4중나선 구조. G-Quadruplex
This 3D-structure of [DNA] is formed in the [Telomere] region and inhibit the telemrase. In addition, it has been found in the [Promoter] region of several [Gene]s inclucing OncoGene. Recently, there has been many interests in G-quadruplex stabiling ligands as anti-cancer. When the G-quadruplex is formed,RNA polymerase or telomerase can't move forward and then, the product, transcript or telomere which induces cellular transformation, is not generated.
In addition, [RNA] G-Quadruplexes have been found in [HIV] and human. Human RNA G-quadruplexes play roles in regulating RNA-processing like polyadenylation or RnaSplicing.
관련프로그램 및 Database