2005-10-01

시월을 맞이하여 새로운 기사내용 두가지

[http://www.biologynews.net/archives/2005/09/29/novel_mechanism_for_dna_replication_discovered.html Novel mechanism for DNA replication discovered]

{{|Aneel Aggarwal, PhD, and Deepak Nair, PhD, of the Department of Physiology and Biophysics at Mount Sinai School of Medicine and their colleagues at University of Texas Medical Branch, Galveston discovered that a protein called Rev1 DNA polymerase itself codes for a cytosine to be placed on the replicating strand. The cytosine is inserted based upon the coding information in Rev1 regardless of whether a guanine or another base is present on the DNA.|}}

• : 일반적으로 DNA replication은 DNA template와 상보적인 sequence를 생성하는 방식인데, protein도 특정한 상황에서 DNA template로 작용한다는 이야기 같음.(읽어보고 아니면 수정해 주세요.) -- ["terra19"] DateTime(2005-10-01T02:45:00Z)

[http://www.biologynews.net/archives/2005/09/29/fruit_fly_studies_open_new_window_on_cancer_research.html Fruit fly studies open new window on cancer research]

{{|The researchers at the University of Oxford, funded in part by the Biotechnology and Biological Sciences Research Council (BBSRC), discovered that this family of amino acid transporters are very powerful growth promoters. When the transporters were overexpressed in a fly, its cells became hypersensitive to insulin-like molecules in the body that have a long-term role in promoting cell growth and development and the cells grew excessively.|}}

• : transporter에 이상이 생기면 초파리의 성장이 감소해서, 만약, human의 경우에도 이러한 mechanism이 있다면, cancer나 diabetes와 같은 질병의 연구에 도움이 될것이다라고 말함. 그러고 보니, microarray data를 분석했을 때 animo acid transporter GO term이 의미있는 것으로 나왔었던것 같다. -- ["terra19"] DateTime(2005-10-01T02:45:00Z)

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