2006-11-17

• 연세 암연구소 국제 암 심포지움 : 주제 - "Emerging role of Nanomedicine: Opportunities and Challenges"

2006-11-15

• 옛말에 머리가 복잡해지고, 무엇을 해야 할지 모를때에는 "처음으로 돌아가라."고 했다. 그래서, 처음으로 돌아가려 한다.

2006-11-14

• [http://www.biologynews.net/archives/2006/11/13/novel_vaccine_shows_promise_against_earlystage_breast_cancer.html novel vaccine shows promise against earlystage breast cancer] -- Biology News Net

{{| Patients with HER-2/neu overexpression were given a therapy of dendritic cells (DC, which work with the B- and T-cells to trigger immune responses) that were treated with HER-2/neu to evoke an immune response. The participants received four weekly vaccinations into normal lymph nodes in their groins and were evaluated both pre- and post-vaccination for immune response, level of HER-2/neu expression, and cell infiltrates. |}}

• : 초기 단계의 유방암인 DCIS(ductal carcinomas in situ, or early stage cancer formation in the breast's milk ducts)는 50~60%가 HER-2/neu over-expression하는 세포들이 주를 이루는 데, Immune Cell인 [DC]([DendriticCell])을 이용하여 미리 [DC]를 HER-2/neu로 교육시킨 후, 환자의 몸에 다시 넣게 되면 [DC]는 T cell에게 알려주는 역할을 하게되고, CD4+ T cells이 HER-2/neu를 over-expression하는 세포를 찾아서 없애게 된다.

2006-11-13

• [http://www.mindprism.co.kr/room/03pictureNessay/list.asp 정혜신의 그림 에세이]

• [http://www.biologynews.net/archives/2006/11/11/one_signal_elicits_thousands_of_answers.html one signal elicits thousands of answers] -- Biology News Net

{{| Cell signaling mechanisms often transmit information via protein modifications, most importantly the reversible attachment of phosphate, the so-called protein phosphorylation. Researchers at the Max Planck Institute of Biochemistry in Martinsried have now developed a technology to identify and quantify the specific sites in proteins that get phosphorylated in answer to certain stimuli in living cells. Under the lead of Matthias Mann, the scientists found 6,600 phosphorylation sites - 90 percent of which were unknown - in 2,244 proteins and observed their temporal dynamics. All these phosphorylation sites are now listed in the newly created Phosida database to make them available for efficient use by scientists working in different areas, among them tumour researchers: Defects in cellular signaling often occur in many types of cancer (Cell, November 2, 2006). |}}

2006-11-10

• [http://www.likejazz.com/archives/62 The django Book] -- likejazz.COM blog

  • : 다른 분들께서 언급하셨듯이 코멘트 다는 것이 정말 예술이군요.

2006-11-09

• [http://ne4jin.com/sabper/90 조각모음 후 컴퓨터 자동종료하기]

• 장문의 글을 다쓰고 미리보기를 눌렀다가, 저장하기 전에 창을 닫아 버렸음...

• [http://www.biologynews.net/archives/2006/11/08/comprehensive_model_is_first_to_map_protein_folding_at_atomic_level.html comprehensive model is first to map protein folding at atomic level] -- Biology News Net

{{| The model developed by Shakhnovich and colleagues faithfully describes and catalogs countless interactions between the individual atoms that comprise proteins. In so doing, it essentially predicts, given a string of amino acids, how the resulting protein will fold -- the first computer model to fully replicate folding of a protein as happens in nature. In more than 4,000 simulations conducted by the researchers, the computer model consistently predicted folded structures nearly identical to those that have been observed experimentally. |}}

• : 단백질의 구조에 이상이 발생하였을 때, 질병이 생긴다는 것은 오래전 부터 알려졌었고 이러한 사실 때문에 질병과 관련된 단백질의 구조를 밝히는 것이 매우 중요한 연구분야였다. 본 내용에서는 단백질의 3차구조를 computer를 이용해서 원자적인 수준에서 모델링하는데 처음으로 성공하였다는 내용이다.

2006-11-08

• [http://www.biologynews.net/archives/2006/11/07/protein_structure_initiative_launches_new_resources_for_the_scientific_community.html protein structure initiative launches new resources for the scientific community] -- Biology News Net

{{| Next year, it will create an information hub where researchers can search for and submit structural information. Meanwhile, PSI scientists will continue to develop new methods and tools for protein structure studies that are being commercialized by industry for mainstream use. |}}

• : PSI라는 protein structure에 관한 정보와 기본 내용들을 보관하고, 그것들을 이용해서 과학자들이 정보를 이용하거나 분석할 수 있도록 하는 community가 있는데, 이러한 노력으로 예전에 비해서 단백질의 구조를 분석하고 이해하는데 많은 시간이나 비용이 줄어들었다. 하지만, 어떻게 보면 이를 통해 미국과 같은 나라가 앞으로 전개될 생명공학 산업에서 엄청난 지식을 선점하고 있다는 이야기로도 볼 수 있기 때문에 후진국들과 비교했을 때 지식에 대한 격차가 벌어질 수도 있다고 생각한다.

2006-11-03

• [http://www.biologynews.net/archives/2006/11/02/single_molecule_extends_fat_mice_lives_by_reversing_gene_pathways_associated_with_disease_in_obese.html single molecule extends fat mice lives by reversing gene pathways associated with disease in obese] -- Biology News Net

{{| "The "healthspan" benefits we saw in the obese mice treated with resveratrol, such as increased insulin sensitivity, decreased glucose levels, healthier heart and liver tissues, are positive clinical indicators and may mean we can stave off in humans age-related diseases such as type 2 diabetes, heart disease, and cancer, but only time and more research will tell," says Sinclair, who is also a co-founder of Sirtris, a company with an author on this paper and which is currently in a phase 1b trial in humans with diabetes using an enhanced, proprietary formulation of resveratrol. |}}

• : mouse를 가지고 standard diet (SD), high calorie diet (HC), treated with resveratrol (HCR) 이렇게 세그룹으로 나누어서 실험을 진행하였는 데, HC에 비해서 HCR이 거의 SD와 같은 상태를 유지하는 것으로 나타났다. 즉, resveratrol을 투여한 쥐는 fat이 첨가된 고열량 식사를 했지만 건강하고 오랜기간 동안 수명을 유지하였다.

2006-11-01

• VectorNti를 academic version으로는 공짜로 쓸 수 있다고 해서, web site에 들어갔는데, login이나 registration을 하는 페이지로 이동이 안 된다. 어떻게 한거냐?

• [http://www.biologynews.net/archives/2006/10/30/adults_who_go_to_bed_lonely_get_stress_hormone_boost_next_morning.html adults who go to bed lonely get stress hormone boost next morning] -- Biology News Net

{{|In addition to noting that loneliness the night before predicted higher cortisol the next morning, Adam and colleagues found that people who experience anger throughout the day have higher bedtime levels of cortisol and flatter overall levels of the stress hormone, typically considered a risk factor for disorder. "High levels of cortisol in the evening are a kind of biological signature of a bad day," Adam noted.

The study also provided evidence that, in addition to simply being at the mercy of your daily experiences, cortisol also plays a role in influencing them. Individuals with lower levels of cortisol in the morning experienced greater fatigue during the day, a result with potential implications for understanding chronic fatigue.|}}

• : 10월의 마지막 밤을 무사히 보내고, 상쾌한 마음으로 실험실에 왔는데, 뭔 이런 cortisol level 올라가는 내용이라니...

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