2007-06-12

• [http://www.biologynews.net/archives/2007/06/11/um_researchers_discover_gene_switched_off_in_cancer_can_be_turned_on.html um researchers discover gene switched off in cancer can be turned on] -- Biology News Net

{{| U-M researchers found that a gene called Brahma, or BRM, is silent – but not missing – in some cancer cells. By exposing the BRM protein to an inhibitor drug, the researchers were able to turn the gene back on, allowing BRM to be expressed. The researchers found this gene is turned off in about 15 percent of tumors studied, including cells from lung, esophageal, ovarian, bladder, colon and breast cancers. |}}

• : 항암 치료에 관한 방법 중에서 [Cell] growth를 조절하는 [Gene]이 silence되어있는 상태를 다시 switch on 상태로 돌려놓게 되면, [Cancer]를 치료할 수 있다는 내용. 본 내용보다 마지막 문장이 마음에 와닿는다. 앞으로 항암치료가 발전하는 방향이라고 해야겠다.

{{| “Targeted therapies are now opening the door, because they are essentially given only to those patients who have a high likelihood of response. Their low toxicity means the patient can be treated for long periods of time, which is unlike older and more traditional chemotherapy agents. Even if these new targeted therapies don’t cure the cancer, we can at least have long-term survival,” he adds. |}}

2007-06-11

• [http://bric.postech.ac.kr/biotrend/retrend/retrend_view.php?nNum=127572 일상적 질병발생과 연관된 유전자 발견과 그 의의] -- Bric

2007-06-07

• [http://www.biologynews.net/archives/2007/06/06/how_to_lose_weight_and_not_go_hungry_hu_researcher_develops_drug_that_mimics_feeling_of_fullness.html how to lose weight and not go hungry hu researcher develops drug that mimics feeling of fullness] -- Biology News Net

{{| Linde and his associates have developed a compound that mimics the activity of the naturally occurring hormone called aMSH. This hormone is naturally excreted during eating and binds to a receptor in the brain called MC4R. When this “communication” occurs on a substantial level, the brain sends out a signal that one feels “full.”

The young Hebrew university researchers developed a novel method for synthesizing a peptide (a peptide is a compound linking two or more amino acids) which can serve as an analog to the naturally occurring aMSH hormone. They were able to demonstrate that their peptide, which they call BL-3020, displayed good metabolic stability to intestinal enzymes when swallowed, and that it was able to cross the intestinal wall and gain access into the blood stream. Once in the blood, it could make its way to the MC4R receptor and “close the circuit” to send out the “full” signal.|}} : 본 내용은 음식을 먹게되면 분비되는 호르몬이 뇌에 포만감을 느끼게 해주는데, 그 호르몬과 비슷한 단백질을 합성하여, 그 단백질을 투여하면 포만감을 느끼게 하므로써, 음식물의 섭취량을 줄일 수 있게되고, 이로 인해 체중을 줄이는 방법이다.

2007-06-05

• 이래저래 지난 달은 안좋은 일이 많았다. 이번 달부터는 좀 좋아지길....

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