HiroakiKitano저서의 SystemsBiology에 관한 책

새롭게 부각되는 SystemsBiology는 생물체를 분자에서부터 세포레벨 더 나아가 행태까지의 모든 레벨에서 실험, 이론 및 예측기법등을 활용하여 연구하는 것을 포함한다. SystemsBiology의 궁극적 목적은 각각의 부분을 나누어서 연구하던 것과는 달리 생물체의 전체 생물학적 과정들을 전체적으로 이해하는 데 있다. 이 분야의 연구는 진보된 MolecularBiology의 기술이 발전함에 따라 가능해졌으며, 이책에서는 시스템생물학 분야의 전반적인 것을 이해하고, 현재 시스템생물학분야의 연구과제등을 다룬다.

목차

1. SystemsBiology : Toward system-level understanding of biological systems

2. Automatic acquisition of cell lineage through 4D microscopy and analysis of early C. elegans embryogenesis

3. The DBRF method for inferring a GeneNetwork from large-scale steady-state gene expression data

4. The analysis of cancer associated gene expression matrices

5. Automated ReverseEngineering of MetabolicPathway from observed data by means of GeneticAlgorithm

6. The ERATO systems biology workbench : an integrated environment for multiscale and multitheoretic simulations in SystemsBiology

7. Automatic model generation for signal transduction with applications to MAP-kinase pathways

8. Modeling large biological systems from functional genomic data : ParameterEstimation

9. Towards a virtual biological laboratory

10. Computational CellBiology - The stochastic approach

11. Computer simulation of the [Cell] : Human erythrocyte model and its application

12. Construting mathematical models of biological SignalTransduction pathways : an analysis of robustness

13. Combination of biphasic response regulation and PositiveFeedback as a general regulatory mechanism in homeostasis and SignalTransduction

14. Distinct roles of Rho-kinase pathway and myosin light chain kinase pathway in phosphorylation of myosin light chain : kinetic simulation study

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