Homology_modeling

Also known as Comparative modeling. Building a three dimensional model of a protein from known sequence but unknown structure, using known related structures as template.

Fold regognition 과 threading 과는 유사성 정도의 차이가 있다.

software

• COMPOSER

• SwissModel

• MODELLER : CASP good result

a-helix is more stronger for mutation than b-sheet

SVR loop model : SLOOP database : 7 AA (ex. E10E)

EHLC