BioHackersNet|
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← Revision 4 as of 2012-06-05 13:36:26 ⇥
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| lung [Cancer]. | lung [[Cancer]]. |
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| ''5p,8p,11p'' and other [Allele] losses [Microsatellite] alterations | ''5p,8p,11p'' and other [[Allele]] losses [[Microsatellite]] alterations |
lung Cancer.
발생에 관여되는 위험 인자
- 흡연 : 직접 흡연(비흡연자의 13배), 간접 흡연(비흡연자의 1.5배)
- 대기 오염
- 직업 : E.g. 비소 관련 직업에서의 평편상피세포 폐암
- 유전적 소인
- 식이 : 저 비타민 A 식이
폐암의 4가지 조직형
- 편평 상피 세포암 (Squamous cell Carcinoma)
- 선암 (Adenocarcinoma)
- 대세포암 (Large cell Carcinoma)
- 소세포암 (Small cell Carcinoma)
소세포암과 관련된 OncoGene
Reccessive OncoGene & allelotype
3p deletions, Rb mutations, p16/CDKN2 mutations, p53 mutations, 5p,8p,11p and other Allele losses Microsatellite alterations
Dominant OncoGene
ras mutations, myc family overexpression, bcl-2 overexpression, Her-2/neu overexpression, Telomerase overxpression