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| '''Rosetta''' is one of the currently most successful ab initio methods developed by the group of David Baker | '''Rosetta''' is one of the currently most successful AbInitio methods developed by the group of DavidBaker |
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| In the Rosetta method, the chain of a protein is broken into three or nine residue segments. A search in [http://www.robetta.com/fragmentqueue.jsp the fragment library] was carried out to obtain the distribution of the conformations for each target segment. Then a conformation space was built from the insertion of the segments. New improved Rosetta used a sequence and secondary structure profile-profile camparsion method to do the searching from the fragment library. And then a Monte Carlo Simulated Annealing procedure was used to select favorable structures from the conformation space with an improved energy function. Since lots of decoy structures were generated during the process, a final filtering and clustering procedure was used to select the candidates from the decoys. | http://www.bakerlab.org/ |
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| 철자검색기는 제대로 동작하는건가요? 그냥 막 쳐서 틀린철자 많을지도 모르는데 ;; 고쳐주세요~ | In the Rosetta method, the chain of a protein is broken into three or nine residue segments. A search in [http://www.robetta.com/fragmentqueue.jsp the fragment library] was carried out to obtain the distribution of the conformations for each target segment. Then a conformation space was built from the insertion of the segments. New improved Rosetta used a sequence and secondary structure profile-profile camparsion method to do the searching from the fragment library. And then a MonteCarloMethod - SimulatedAnnealing procedure was used to select favorable structures from the conformation space with an improved energy function. Since lots of decoy structures were generated during the process, a final filtering and [Clustering] procedure was used to select the candidates from the decoys. You can contribute the calculation via RosettaAtHome. 철자검색기는 제대로 동작하는건가요? 그냥 막 쳐서 틀린철자 많을지도 모르는데 ;; 고쳐주세요~ --[wsjoung] |
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| CategoryProtein | = Rosetta 관련 논문들 = == Toward High-Resolution de Novo Structure Prediction for Small Proteins == Rosetta 가 사용하는 low-resolution 과 high-resolution 을 조합한 구조 예측 방법이 소개 되어 있다. * [http://www.sciencemag.org/cgi/content/full/309/5742/1868 Toward High-Resolution de Novo Structure Prediction for Small Proteins] ---- CategoryProgram |
Rosetta is one of the currently most successful AbInitio methods developed by the group of DavidBaker
In the Rosetta method, the chain of a protein is broken into three or nine residue segments. A search in [http://www.robetta.com/fragmentqueue.jsp the fragment library] was carried out to obtain the distribution of the conformations for each target segment. Then a conformation space was built from the insertion of the segments. New improved Rosetta used a sequence and secondary structure profile-profile camparsion method to do the searching from the fragment library.
And then a MonteCarloMethod - SimulatedAnnealing procedure was used to select favorable structures from the conformation space with an improved energy function. Since lots of decoy structures were generated during the process, a final filtering and [Clustering] procedure was used to select the candidates from the decoys.
You can contribute the calculation via RosettaAtHome.
철자검색기는 제대로 동작하는건가요? 그냥 막 쳐서 틀린철자 많을지도 모르는데 ;; 고쳐주세요~ --[wsjoung]
Rosetta 관련 논문들
Toward High-Resolution de Novo Structure Prediction for Small Proteins
Rosetta 가 사용하는 low-resolution 과 high-resolution 을 조합한 구조 예측 방법이 소개 되어 있다.
[http://www.sciencemag.org/cgi/content/full/309/5742/1868 Toward High-Resolution de Novo Structure Prediction for Small Proteins]