Rosetta is one of the currently most successful AbInitio methods developed by the group of DavidBaker

http://www.bakerlab.org/

In the Rosetta method, the chain of a protein is broken into three or nine residue segments. A search in [http://www.robetta.com/fragmentqueue.jsp the fragment library] was carried out to obtain the distribution of the conformations for each target segment. Then a conformation space was built from the insertion of the segments. New improved Rosetta used a sequence and secondary structure profile-profile camparsion method to do the searching from the fragment library.

And then a MonteCarloMethod - SimulatedAnnealing procedure was used to select favorable structures from the conformation space with an improved energy function. Since lots of decoy structures were generated during the process, a final filtering and [Clustering] procedure was used to select the candidates from the decoys.

You can contribute the calculation via RosettaAtHome.

철자검색기는 제대로 동작하는건가요? 그냥 막 쳐서 틀린철자 많을지도 모르는데 ;; 고쳐주세요~ --[wsjoung]

Rosetta 관련 논문들

• [http://www.sciencemag.org/cgi/content/full/309/5742/1868 Toward High-Resolution de Novo Structure Prediction for Small Proteins]

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