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| [http://www.nature.com/embor/journal/v5/n7/full/7400186.html AAA Protease] | [[http://www.nature.com/embor/journal/v5/n7/full/7400186.html|AAA Protease]] |
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| [http://www.ch.embnet.org/CoursEMBnet/PagesPHYL07/Exercises/day2/day2.html dS/dN ratio] [http://pubmlst.org/software/analysis/start/manual/dsdn.shtml dS/dN ratio2] | [[http://www.ch.embnet.org/CoursEMBnet/PagesPHYL07/Exercises/day2/day2.html|dS/dN ratio]] [[http://pubmlst.org/software/analysis/start/manual/dsdn.shtml|dS/dN ratio2]] |
Destine
이름 : 양재성 ( Jae Seong Yang )
Ph.D. course in I-BIO Program at POSTECH
B.S. Life Science & Computer Science at POSTECH
http://home.postech.ac.kr/~destine
Nucleotide substitition이 일어났을 때, Amino acid가 변하기도 하고 변하지 않기도 한다. Amino acid가 변하는 mutation을 non-synonymous mutation이라고 하고, amino acid가 변하지 않는 mutation을 synonymous mutation이라고 한다. 이 synonymous mutation과 non-synonymous mutation의 ratio를 이용해서 어떤 단백질이 positive selection을 하는지 purifying selection을 하는지 추정해 볼 수 있다.