BioHackersNet|
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| == [Genome] vs [Proteome] == | == Genome vs Proteome == |
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| || genetic information || function || | || '''genetic information''' || '''function''' || |
Proteins complement expressed by a genome or tissue --Wilkins et at. 1995 BiotechnologyAndGeneticEngineeringReviews 12, 19-50
특정개체의 특정상태에서의 모든 [Proteins], [Genome]이 모든 cell이 가지고 있는 같은 정보임에 비해, [Proteome]은 cell specific한 정보이다.
While [Genome] is a static repository of information whose contents do not change with time, the [Proteome] is highly dynamic, with the subset of [Proteins] expressed changing from moment to moment according to the developmental and physiological state of the cell. -- in ProteomicsFromProteinSequenceToFunction
Proteomes change as a function of:
- time
- development
- intracellular
- extracellular
Genome vs Proteome
genetic information |
function |
[DNA] |
[Proteins] |
100,000 ~ 120,000 |
500,000 ~ 2,000,000 |
static-no complexity |
dynamic-very complex |
amplify |
can't amplify |
mapping and sequencing |
separation and characterization |
near completion |
early stage |
[Genomics] |
[Proteomics] |
[Gene]-[Genome]-[Genomics]와 같은 맥락으로 [Protein]-[Proteome]-[Proteomics]의 개념이다.