Proteins complement expressed by a genome or tissue --Wilkins et at. 1995 BiotechnologyAndGeneticEngineeringReviews 12, 19-50

특정개체의 특정상태에서의 모든 [Proteins], [Genome]이 모든 cell이 가지고 있는 같은 정보임에 비해, [Proteome]은 cell specific한 정보이다.

While [Genome] is a static repository of information whose contents do not change with time, the [Proteome] is highly dynamic, with the subset of [Proteins] expressed changing from moment to moment according to the developmental and physiological state of the cell. -- in ProteomicsFromProteinSequenceToFunction

Proteomes change as a function of:

  • time
  • development
  • intracellular
  • extracellular

Genome vs Proteome

genetic information

function

[DNA]

[Proteins]

100,000 ~ 120,000

500,000 ~ 2,000,000

static-no complexity

dynamic-very complex

amplify

can't amplify

mapping and sequencing

separation and characterization

near completion

early stage

[Genomics]

[Proteomics]


[Gene]-[Genome]-[Genomics]와 같은 맥락으로 [Protein]-[Proteome]-[Proteomics]의 개념이다.

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