Method of ParametricSequenceAnalysis
긴 서열에 대해 Windows size와 step size를 정한다. 그 후 step size만큼 이동하면서, windows size내에 있는 서열들의 특이성을 수치화한다. 이 방법으로 할 수 있는 분석방법들
- GC-contents
- Hydrophobisity
Window size
- if too big, the resulting plot is smoothened.
- if too small, the resulting plot fluctuates too much.
- you have to choose a "good" window size somewhere in between these two extremes.
Step size
- doesn't have as dramatic effect as window size
- relatively smaller than the size of the signal. otherwise, you can miss the signal by jumping over it.