BioinformaticsInformation의 메일링리스트에 소개된 현재 생물정보학의 10대 도전과제
Ewan Birney, Chris Burge, Jim Fickett in Genome Technology, Jan 2002
- Precise, predictive model of transcription initiation and termination : ability to predict where and when transcription will occur in a [Genome]
Precise, predictive model of RnaSplicing / AlternativeSplicing : ability to predict the splicing pattern of any primary transcript in any tissue
Precise, quantitative models of SignalTransduction pathways : ability to predict cellular responses to external stimuli
Determining effective Protein-DNA, Protein-RNA and Protein-Protein recognition codes
Accurate AbInitio ProteinStructure Prediction
- Rational design of small molecule inhibitors of proteins
- Mechanistic understanding of protein evolution : understanding exactly how new protein functions evolve
Mechanistic understanding of Speciation : molecular details of how speciation occurs
Continued development of effective GeneOntology systematic ways to describe the functions of any Gene or Protein
- Education : development of appropriate bioinformatics curricula for high school, undergraduate, and graduate programs
Concerned post