BioinformaticsInformation의 메일링리스트에 소개된 현재 생물정보학의 10대 도전과제

Ewan Birney, Chris Burge, Jim Fickett in Genome Technology, Jan 2002

  1. Precise, predictive model of transcription initiation and termination : ability to predict where and when transcription will occur in a [Genome]
  2. Precise, predictive model of RnaSplicing / AlternativeSplicing : ability to predict the splicing pattern of any primary transcript in any tissue

  3. Precise, quantitative models of SignalTransduction pathways : ability to predict cellular responses to external stimuli

  4. Determining effective Protein-DNA, Protein-RNA and Protein-Protein recognition codes

  5. Accurate AbInitio ProteinStructure Prediction

  6. Rational design of small molecule inhibitors of proteins
  7. Mechanistic understanding of protein evolution : understanding exactly how new protein functions evolve
  8. Mechanistic understanding of Speciation : molecular details of how speciation occurs

  9. Continued development of effective GeneOntology systematic ways to describe the functions of any Gene or Protein

  10. Education : development of appropriate bioinformatics curricula for high school, undergraduate, and graduate programs

Concerned post

  1. Top Bioinformatics Challenges (Chris Burge et al.)


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TopTenBioinformaticsChallenges (last edited 2011-08-25 20:36:36 by 211)

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