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'''Prote'''ins complement expressed by a gen'''ome''' or tissue --Wilkins et at. 1995 ''BiotechnologyAndGeneticEngineeringReviews'' 12, 19-50 |
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특정개체의 특정상태에서의 모든 [[Proteins]], [[Genome]]이 모든 cell이 가지고 있는 같은 정보임에 비해, [[Proteome]]은 cell specific한 정보이다. |
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While [[Genome]] is a static repository of information whose contents do not change with time, the [[Proteome]] is highly dynamic, with the subset of [[Proteins]] expressed changing from moment to moment according to the developmental and physiological state of the cell. -- in ProteomicsFromProteinSequenceToFunction Proteomes change as a function of: * time * development * intracellular * extracellular == Genome vs Proteome == || '''genetic information''' || '''function''' || || [[DNA]] || [[Proteins]] || || 100,000 ~ 120,000 || 500,000 ~ 2,000,000 || || static-no complexity || dynamic-very complex || || amplify || can't amplify || || mapping and sequencing || separation and characterization || || near completion || early stage || || [[Genomics]] || [[Proteomics]] || |
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---- [[Gene]]-[[Genome]]-[[Genomics]]와 같은 맥락으로 [[Protein]]-[[Proteome]]-[[Proteomics]]의 개념이다. |
Proteins complement expressed by a genome or tissue --Wilkins et at. 1995 BiotechnologyAndGeneticEngineeringReviews 12, 19-50
특정개체의 특정상태에서의 모든 Proteins, Genome이 모든 cell이 가지고 있는 같은 정보임에 비해, Proteome은 cell specific한 정보이다.
While Genome is a static repository of information whose contents do not change with time, the Proteome is highly dynamic, with the subset of Proteins expressed changing from moment to moment according to the developmental and physiological state of the cell. -- in ProteomicsFromProteinSequenceToFunction
Proteomes change as a function of:
- time
- development
- intracellular
- extracellular
Genome vs Proteome
genetic information |
function |
100,000 ~ 120,000 |
500,000 ~ 2,000,000 |
static-no complexity |
dynamic-very complex |
amplify |
can't amplify |
mapping and sequencing |
separation and characterization |
near completion |
early stage |
Gene-Genome-Genomics와 같은 맥락으로 Protein-Proteome-Proteomics의 개념이다.